Background and Objectives : Despite of numerous treatment modalities for glottic
insufficiency, it still remains unresolved problem. Recently, autologous collagen injection
was introduced as a new treatment far glottic insufficiency. This study was attempted
to evaluate the efficacy of this treatment modality.
Materials and Methods : Ten patients diagnosed as symptomatic sulcus vocalis with
glottic insufficiency and agreed with this procedure were selected. Injectable collagen
was obtained from the patient's dermis. It was injected into the pathologic area of the
vocal fold. After injection, 4 of 10 patients were followed up more than 5 months, and
their voice were evaluated prior to injection and at 5 months artier injection, using
subjective, perceptual, aerodynamic, acoustic and videostroboscopic assessments.
Results : In the aerodynamic assessment, 2 of 4(50%) patients was improved in
MFR(mean flow rate), but no change was noted in MPT(maximum phonation time). In
the acoustic assessment, no definite improvement was noted. In the subjective and
perceptual assessments,2 of 4(50%) patients was improved. In the videostroboscopic
assessment, chink was reduced but still remained. Serious complication was not noted.
Conclusion : Autologous collagen injection was reported as ideal treatment for glottic
insufficiency, but our results were relatively unsatisfactory. But considering that our
study is preliminary, it is too hasty to determine the efficacy of autologous collagen
injection. We think that further study is required.
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